Assessment of airway microbiota and inflammation in cystic fibrosis using multiple sampling methods.

@article{Zemanick2015AssessmentOA,
  title={Assessment of airway microbiota and inflammation in cystic fibrosis using multiple sampling methods.},
  author={Edith T Zemanick and Brandie D. Wagner and Charles E. Robertson and Mark J. Stevens and Stanley J Szefler and Frank Accurso and Scott D Sagel and J. Kirk Harris},
  journal={Annals of the American Thoracic Society},
  year={2015},
  volume={12 2},
  pages={221-9}
}
RATIONALE Oropharyngeal (OP) swabs and induced sputum (IS) are used for airway bacteria surveillance in nonexpectorating children with cystic fibrosis (CF). Molecular analyses of these airway samples detect complex microbial communities. However, the optimal noninvasive sampling approach for microbiota analyses and the clinical relevance of microbiota, particularly its relationship to airway inflammation, is not well characterized. OBJECTIVES The goals of this study were to compare molecular… CONTINUE READING
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