Assessment of a model for the opposing effects of N-ethylmaleimide on the affinity of muscarinic agonists for M2 receptors.

@article{Dawson1992AssessmentOA,
  title={Assessment of a model for the opposing effects of N-ethylmaleimide on the affinity of muscarinic agonists for M2 receptors.},
  author={Raymond Murray Dawson and M Poretski},
  journal={General pharmacology},
  year={1992},
  volume={23 3},
  pages={331-5}
}
1. Homogenates of guinea pig right atrium (M2 receptors) were treated with N-ethylmaleimide, after which the ability of carbachol to inhibit binding of [3H]quinuclidinyl benzilate was studied. 2. At 37 degrees C, 10(-4) M and 10(-3) M, but not 10(-5) M, N-ethylmaleimide increased the affinity of carbachol for the receptor. At 2 degrees C, 10(-5) M and 10(-4… CONTINUE READING