Assessment of a combined, adenovirus-mediated oncolytic and immunostimulatory tumor therapy.

@article{Bernt2005AssessmentOA,
  title={Assessment of a combined, adenovirus-mediated oncolytic and immunostimulatory tumor therapy.},
  author={Kathrin Maria Bernt and Shaoheng Ni and A Tieu and Andr{\'e} Lieber},
  journal={Cancer research},
  year={2005},
  volume={65 10},
  pages={4343-52}
}
In this study, we identified murine breast cancer cell lines that support DNA replication of E1-deleted adenovirus vectors and which can be killed by an oncolytic adenovirus expressing adenovirus E1A and tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) in a replication-dependent manner (Ad.IR-E1A/TRAIL). We showed that systemic or… CONTINUE READING