Assessment of a cholinergic contribution to chlordiazepoxide-induced deficits of place learning in the Morris water maze

@article{McNamara1992AssessmentOA,
  title={Assessment of a cholinergic contribution to chlordiazepoxide-induced deficits of place learning in the Morris water maze},
  author={R. McNamara and R. Skelton},
  journal={Pharmacology Biochemistry and Behavior},
  year={1992},
  volume={41},
  pages={529-538}
}
This investigation sought to characterize the interaction between benzodiazepine and cholinergic systems in place learning in the Morris water maze. In the first experiment, rats were treated with scopolamine (1 mg/kg) alone or concomitantly with one of two doses of flumazenil (15 and 30 mg/kg) or with chlordiazepoxide (5 mg/kg) alone or concomitantly with flumazenil (15 mg/kg). Chlordiazepoxide and scopolamine severely impaired place learning but not cue learning. The low dose of flumazenil… Expand
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