Assessment of a HER2 scoring system for colorectal cancer: results from a validation study

  title={Assessment of a HER2 scoring system for colorectal cancer: results from a validation study},
  author={Emanuele Valtorta and Cosimo Martino and Andrea Sartore-Bianchi and Fr{\'e}d{\'e}rique Penaullt-Llorca and Giuseppe Viale and Mauro Risio and M Rugge and Walter Franco Grigioni and Katia Bruna Bencardino and Sara Lonardi and Vittorina Zagonel and Francesco Leone and Johannes No{\'e} and Fortunato Ciardiello and Carmine Pinto and Roberto Labianca and Stefania Mosconi and Claudio Graiff and Giuseppe Aprile and Barbara Frau and Carlo Garufi and Fotios Loupakis and Patrizia Racca and Giuseppe Tonini and Calogero Lauricella and Silvio Marco Veronese and Mauro Truini and Salvatore Siena and Silvia Marsoni and Marcello Gambacorta},
  journal={Modern Pathology},
We sought to develop criteria for ERBB2-positivity (HER2) in colorectal cancer to ensure accurate identification of ERBB2-amplified metastatic colorectal cancer patients suitable for enrolment in a phase II trial of ERBB2-targeted therapy (HERACLES trial). A two-step approach was used. In step 1, a consensus panel of pathologists adapted existing protocols for use in colorectal cancer to test ERBB2 expression and amplification. Collegial revision of an archival test cohort of colorectal cancer… CONTINUE READING
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