Assessment of a DNA vaccine encoding an anchored-glycosylphosphatidylinositol tegumental antigen complexed to protamine sulphate on immunoprotection against murine schistosomiasis.

@article{Nascimento2007AssessmentOA,
  title={Assessment of a DNA vaccine encoding an anchored-glycosylphosphatidylinositol tegumental antigen complexed to protamine sulphate on immunoprotection against murine schistosomiasis.},
  author={Eduardo J M Nascimento and Rosa V Amorim and Andr{\'e} Pinto Cavalcanti and Veruska L. F. Alves and Mineo Nakazawa and Val{\'e}ria Rěgo Alves Pereira and Norma Lucena-Silva},
  journal={Memorias do Instituto Oswaldo Cruz},
  year={2007},
  volume={102 1},
  pages={21-7}
}
Protamine sulphate/DNA complexes have been shown to protect DNA from DNase digestion in a lipid system for gene transfer. A DNA-based vaccine complexed to protamine sulphate was used to induce an immune response against Schistosoma mansoni anchored-glycosylphosphatidylinositol tegumental antigen in BALB/c mice. The protection elicited ranged from 33 to 44%. The spectrum of the elicited immune response induced by the vaccine formulation without protamine was characterized by a high level of IgG… CONTINUE READING

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