Assessment of Topoisomerase II α status in breast cancer by quantitative PCR, gene expression microarrays, immunohistochemistry, and fluorescence in situ hybridization.

@article{Romero2011AssessmentOT,
  title={Assessment of Topoisomerase II α status in breast cancer by quantitative PCR, gene expression microarrays, immunohistochemistry, and fluorescence in situ hybridization.},
  author={Alaitz Romero and Miguel Mart{\'i}n and Maggie C U Cheang and J A L{\'o}pez Garc{\'i}a-Asenjo and Bel{\'e}n Oliva and Xiaping He and Miguel de la Hoya and Jos{\'e} {\'A}ngel Garc{\'i}a Sa{\'e}nz and Manuel Arroyo Fern{\'a}ndez and Eduardo D{\'i}az Rubio and Charles M. Perou and Trinidad Cald{\'e}s Llopis},
  journal={The American journal of pathology},
  year={2011},
  volume={178 4},
  pages={
          1453-60
        }
}
Anthracyclines are frequently used for the treatment of breast cancer and topoisomerase II alpha (TOP2A) is considered to be the molecular target. Numerous studies have evaluated the predictive value of TOP2A using different methodological approaches and inconsistent results have been reported. Indeed, the correlation between techniques for the assessment of TOP2A status has not been well evaluated. In this study, we determined TOP2A status in 61 breast tumor samples by real-time PCR, DNA… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 31 CITATIONS

Estrogen receptor α roles in breast cancer chemoresistance.

  • Asian Pacific journal of cancer prevention : APJCP
  • 2013
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The HER2 amplicon in breast cancer: Topoisomerase IIA and beyond.

  • Biochimica et biophysica acta
  • 2013
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Relationship between Topoisomerase 2A RNA Expression and Recurrence after Adjuvant Chemotherapy for Breast Cancer.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2009

Supervised risk predictor of breast cancer based on intrinsic subtypes.

  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2009
VIEW 3 EXCERPTS