Assessment of Taste and Grittiness of Riomet® ER Strawberry, Riomet® ER Grape, Riomet® Cherry, and Metformin Immediate-Release Tablets in Healthy Subjects

@article{Marshall2019AssessmentOT,
  title={Assessment of Taste and Grittiness of Riomet{\textregistered} ER Strawberry, Riomet{\textregistered} ER Grape, Riomet{\textregistered} Cherry, and Metformin Immediate-Release Tablets in Healthy Subjects},
  author={Allyson C Marshall and Maureen Damstra and Michael R. Tuley and Elena L Schifando},
  journal={Drugs in R\&D},
  year={2019},
  volume={19},
  pages={57 - 66}
}
ObjectiveThis study was conducted to evaluate the taste and grittiness of two formulations of Riomet® ER (metformin hydrochloride for extended release [ER] oral suspension 100 mg/mL) differing only in their flavoring agents (strawberry and grape) in comparison with two commercially available immediate-release (IR) formulations of metformin, Riomet® Cherry (metformin hydrochloride oral solution 500 mg/5 mL) and metformin IR tablets (metformin hydrochloride IR tablets 500 mg), in healthy human… 

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References

SHOWING 1-10 OF 43 REFERENCES

Open-Label Taste-Testing Study to Evaluate the Acceptability of Both Strawberry-Flavored and Orange-Flavored Amylmetacresol/2,4-Dichlorobenzyl Alcohol Throat Lozenges in Healthy Children

Evaluating the acceptability of two licensed, commercially available sore throat lozenges containing amylmetacresol and 2,4-dichlorobenzyl (AMC/DCBA)—one strawberry flavored and the other orange flavored—in healthy children found both strawberry and orange would be suitable flavors for lozenge intended for children when they suffer from sore throat.

Children’s perceptions about medicines: individual differences and taste

Individual differences in taste responses to medications highlight the need to consider children’s genetic variation and their own perceptions when developing formulations acceptable to the pediatric palate.

Prescribing for children – taste and palatability affect adherence to antibiotics: a review

Palatability is important in the broader context of global child health as regards the successful treatment of malaria, HIV and dehydration and the hidden cost of poor adherence resulting treatment failure, complications and the development of drug resistance cannot be over emphasised.

A spoonful of sugar helps the medicine go down? A review of strategies for making pills easier to swallow

People with pill-swallowing difficulties can benefit from a number of strategies designed to facilitate swallowing medications, however, these strategies should be further evaluated with regard to the evidence relating to both their efficacy and safety.

Adherence to Oral Glucose-Lowering Therapies and Associations With 1-Year HbA1c: A Retrospective Cohort Analysis in a Large Primary Care Database

Reduced medication adherence for commonly used glucose-lowering therapies among patients persisting with treatment is associated with smaller HbA1c reductions compared with those taking treatment as recommended.

Swallowing difficulties with oral drugs among polypharmacy patients attending community pharmacies

A fairly high prevalence of swallowing difficulties in polypharmacy patients attending their community pharmacies is reported, with intentional non adherence and altering the oral dose formulation were the most common and potentially harmful strategies used by patients to overcome their swallowing difficulties.

Patient-Centered Pharmaceutical Design to Improve Acceptability of Medicines: Similarities and Differences in Paediatric and Geriatric Populations

A better understanding of the acceptability of existing formulations highlights opportunities for the development of new and more acceptable medicines and facilitates safe and effective prescribing for the young and older populations.

The Change in HbA1c Associated with Initial Adherence and Subsequent Change in Adherence among Diabetes Patients Newly Initiating Metformin Therapy

Initial adherence to newly prescribed metformin therapy produces substantial HbA1c reduction among those with modest adherence but suboptimal glycemic control, and the difference between moving to full adherence versus nonadherence results in lower Hb a1c of one percentage point.