Assessment of Serum Uric Acid Levels in Multiple Sclerosis during Disease-Modifying Treatment

@article{PodleckaPitowska2018AssessmentOS,
  title={Assessment of Serum Uric Acid Levels in Multiple Sclerosis during Disease-Modifying Treatment},
  author={Aleksandra Podlecka-Piętowska and Joanna Przybek and Kamil Chorążka and Monika Nojszewska and Beata Zakrzewska-Pniewska and Anna Kaminska},
  journal={Journal of multiple sclerosis},
  year={2018},
  volume={5},
  pages={1-3}
}
Objective: Uric acid is a potent endogenous antioxidant and scavenger of peroxynitrite (PN), which hypothesized to be involved in the pathogenesis of multiple sclerosis (MS). Some studies reported lower levels of UA in MS patients compared with controls, whereas other studies found no difference. The main purpose of this analysis was to verify the hypothesis on lower serum levels of UA in MS patients compared with controls.Materials and methods: We examined 80 patients with clinically defined… 
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Tables from this paper

Electrochemical Characterization of Iron (III) Doped Zeolite-Graphite Composite Modified Glassy Carbon Electrode and Its Application for AdsASSWV Determination of Uric Acid in Human Urine
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TLDR
Under optimized method and solution parameters, linear dependence of peak current on uric acid concentration in a wide range of 1-120 μM, low detection limit value, replicate results with low RSD, and excellent recovery results validated the developed adsorptive anodic stripping square wave voltammetric (AdsASSWV) method for determination of uric Acid even in aqueous human urine samples.
Assessment of Serum Uric Acid Levels in Multiple Sclerosis during Disease-Modifying Treatment
TLDR
Data suggest that UA concentration is lower in MS patients than in control group, and it seems that low uric acid levels indicate patients with a higher risk of disease progression.

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