Assessment of Relationship between Wilms' Tumor Gene (WT1) Expression in Peripheral Blood of Acute Leukemia Patients and Serum IL-12 and C3 Levels.

@article{Rezai2015AssessmentOR,
  title={Assessment of Relationship between Wilms' Tumor Gene (WT1) Expression in Peripheral Blood of Acute Leukemia Patients and Serum IL-12 and C3 Levels.},
  author={Omran Rezai and Ali Khodadadi and Yuji Heike and Ali Mostafai and Nader Dashti Gerdabi and Mohammad Rashno and Zahra Abdoli},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2015},
  volume={16 16},
  pages={7303-7}
}
BACKGROUND Leukemia is a common cancer among children and adolescents. Wilms' tumor gene (WT1) is highly expressed in patients with acute leukemia. It is found as a tumor associated antigen (TAA) in various types of hematopoietic malignancies and can be employed as a useful marker for targeted immunotherapy and monitoring of minimal residual disease (MRD). In this regard, WT1 is a transcription factor that promotes gene activation or repression depending on cellular and promoter context. The… CONTINUE READING