Assessment of R18, COG1410, and APP96-110 in Excitotoxicity and Traumatic Brain Injury

@inproceedings{Chiu2017AssessmentOR,
  title={Assessment of R18, COG1410, and APP96-110 in Excitotoxicity and Traumatic Brain Injury},
  author={Li Shan Chiu and Ryan S. Anderton and Jane L. Cross and Vince W. Clark and Adam B Edwards and Neville W. Knuckey and Bruno P Meloni},
  booktitle={Translational neuroscience},
  year={2017}
}
Cationic arginine-rich and poly-arginine peptides (referred to as CARPs) have potent neuroprotective properties in in vitro excitotoxicity and in vivo models of stroke. Traumatic brain injury (TBI) shares many pathophysiological processes as stroke, including excitotoxicity. Therefore, we evaluated our lead peptide, poly-arginine R18, with the COG1410 and APP96-110 peptides, which have neuroprotective actions following TBI. In an in vitro cortical neuronal glutamic acid excitotoxicity injury… CONTINUE READING
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