Assessment of PC12 cell differentiation and neurite growth: a comparison of morphological and neurochemical measures.

@article{Das2004AssessmentOP,
  title={Assessment of PC12 cell differentiation and neurite growth: a comparison of morphological and neurochemical measures.},
  author={Kaberi P. Das and Theresa M. Freudenrich and William R. Mundy},
  journal={Neurotoxicology and teratology},
  year={2004},
  volume={26 3},
  pages={397-406}
}
In vitro techniques are used increasingly to screen for and characterize neurotoxicants. In many cases, chemical-induced injury to developing neurons has been examined in vitro by assessing morphological changes in differentiation and neurite growth. This research evaluated the use of proteins associated with axonal growth and synaptogenesis as surrogates for morphological measurement of neuronal differentiation. PC12 cells, which differentiate upon nerve growth factor (NGF) stimulation, were… CONTINUE READING

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