Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies

  title={Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies},
  author={Cristina Rodriguez-Fontenla and M. Isabel Calaza and Evangelos Evangelou and Ana M Valdes and Nigel K Arden and Francisco J Blanco and Andrew Carr and Kay Chapman and Panagiotis Deloukas and Michael T. Doherty and T{\"o}nu Esko and Carlos M Garc{\'e}s Alet{\'a} and Juan Jes{\'u}s G{\'o}mez-Reino Carnota and Hafdis Th Helgadottir and Albert Hofman and Ingileif J{\'o}nsd{\'o}ttir and Hanneke J M Kerkhof and Margreet Kloppenburg and Andrew McCaskie and Evangelia E. Ntzani and William E. R. Ollier and Natividad Oreiro and Kalliope Panoutsopoulou and Stuart H. Ralston and Yolande F M Ramos and Jos{\'e} A Riancho and Fernando Rivadeneira and Pieternella E Slagboom and Unnur Styrkarsdottir and Unnur Thorsteinsdottir and Gudmar Thorleifsson and Aspasia Tsezou and Andr{\'e} G. Uitterlinden and Gillian A. Wallis and Jeremy Mark Wilkinson and Guangju Zhai and Yongfa Zhu and David T. Felson and John P. A. Ioannidis and John Loughlin and Andres Metspalu and Ingrid Meulenbelt and K{\'a}ri Stef{\'a}nsson and Joyce B. J. van Meurs and Eleftheria Zeggini and Tim D. Spector and Antonio Gonz{\'a}lez},
  booktitle={Arthritis & rheumatology},
OBJECTIVE To assess candidate genes for association with osteoarthritis (OA) and identify promising genetic factors and, secondarily, to assess the candidate gene approach in OA. METHODS A total of 199 candidate genes for association with OA were identified using Human Genome Epidemiology (HuGE) Navigator. All of their single-nucleotide polymorphisms (SNPs) with an allele frequency of >5% were assessed by fixed-effects meta-analysis of 9 genome-wide association studies (GWAS) that included 5… CONTINUE READING