Assessment of Neuropsychological Late Effects in Survivors of Childhood Leukemia

@article{Kalafatlar2014AssessmentON,
  title={Assessment of Neuropsychological Late Effects in Survivors of Childhood Leukemia},
  author={Ayşe İpek Kalafatçılar and {\"O}zlem T{\"u}fekçi and Hale {\"O}ren and Semra Hiz and Handan G{\"u}lery{\"u}z and Aynur Pekcanlar Akay and Esmahan Orçim and Y{\"u}ksel Olgun and G{\"u}lersu Irken},
  journal={Pediatric Hematology and Oncology},
  year={2014},
  volume={31},
  pages={181 - 193}
}
The neurologic dysfunctions caused by treatment may affect health and quality of life in survivors of childhood leukemia. The objective of this study was to identify the neuropsychological late effects of leukemia treatment to provide an assessment about the degree and incidence of these late effects. Neurological and ophtalmological examination, cranial magnetic resonance imaging (MRI), auditory and neurocognitive tests, and questionnaires of quality of life were performed to 44 acute leukemia… Expand
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References

SHOWING 1-10 OF 71 REFERENCES
Magnetic resonance imaging of the brain and neuropsychological evaluation in children treated for acute lymphoblastic leukemia at a young age.
TLDR
Cranial magnetic resonance imaging and neuropsychological assessments were performed in 35 children treated for acute lymphoblastic leukemia with cranial irradiation (CI) and intrathecal and intravenous methotrexate to evaluate the adverse late effects of ALL treatment on cognitive functions and brain morphology. Expand
Magnetic resonance imaging of the brain in survivors of childhood acute lymphoblastic leukemia
TLDR
It is concluded that cranial irradiation is associated with higher incidence of MRI changes in children treated for ALL andLimitation of cranials irradiation to selected patients contributed to a lower incidence of neurological complications in this study. Expand
Cognitive Functioning in Long‐Term Survivors of Childhood Leukemia: A Prospective Analysis
TLDR
The findings indicate the need for annual evaluations of cognitive functioning in long-term survivors of childhood leukemia who received 1800 cGy craniospinal irradiation, to identify potential cognitive late effects of treatment requiring appropriate special education services. Expand
Slight cognitive impairment and magnetic resonance imaging abnormalities but normal school levels in children treated for acute lymphoblastic leukemia with chemotherapy only.
TLDR
Treatment with chemotherapy only may be associated with some cognitive impairment, however, these children attained normal school levels and demonstrated significantly better test results and significantly fewer learning disabilities and MRI abnormalities than did the previously irradiated group. Expand
Late-occurring neurologic sequelae in adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study.
  • R. Goldsby, Qi Liu, +9 authors R. Packer
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2010
TLDR
Children treated with regimens that include cranial radiation for ALL and those who suffer a relapse are at increased risk for late-onset neurologic sequelae, according to multivariable analysis. Expand
Ten-year survey of the intellectual deficits in children with acute lymphoblastic leukemia receiving chemoimmunotherapy.
TLDR
Effects of chemoimmunotherapy, including cranial irradiation for central nervous system (CNS)-directed therapy, on children with acute lymphoblastic leukemia (ALL) were investigated and decreased IQ was related to age at diagnosis and irradiation, irradiation-examination interval, and female sex. Expand
White matter changes on MRI during treatment in children with acute lymphoblastic leukemia: correlation with neuropsychological findings.
TLDR
White matter changes are occasionally observed during therapy with the current Nordic protocols, and young children may be more susceptible to developing white matter changes after repeated intravenous methotrexate injections. Expand
Late Effects of Childhood Acute Leukemia and Its Treatment
TLDR
The results suggest that it is needed to improve therapeutic methods through the stratification of patients by risk factors and detailed analysis of prognostic factors and it is important to render medical and psychosocial support to long‐term survivors of childhood leukemia through interactions between the patient, parents and medical staff. Expand
Prospective evaluation of late effects after childhood cancer therapy with a follow-up over 9 years
TLDR
It is indicated that a considerable number of former paediatric cancer patients suffer from remarkable long-term side-effects, and careful follow-up of long- term survivors is mandatory with the aim to reduce or even abrogate possible side- effects at the earliest time. Expand
Intellectual outcome in children and adolescents with acute lymphoblastic leukaemia treated with chemotherapy alone: age- and sex-related differences.
TLDR
The abandonment of prophylactic CNS irradiation and its replacement by a more intensive systemic and intrathecal chemotherapy led to a reduction, but not the disappearance of late neuropsychological sequelae. Expand
...
1
2
3
4
5
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