Assessment of Mycobacterium tuberculosis pantothenate kinase vulnerability through target knockdown and mechanistically diverse inhibitors.

@article{Reddy2014AssessmentOM,
  title={Assessment of Mycobacterium tuberculosis pantothenate kinase vulnerability through target knockdown and mechanistically diverse inhibitors.},
  author={B. K. Kishore Reddy and Sudhir Landge and Sudha Ravishankar and Vikas Ashok Patil and Vikas Shinde and Subramanyam J. Tantry and Manoj G Kale and Anandkumar Raichurkar and Sreenivasaiah Menasinakai and Naina Vinay Mudugal and Anisha Ambady and Anirban Ghosh and Ragadeepthi Tunduguru and Parvinder Kaur and Ragini Singh and N. Pradeep Kumar and Sowmya Bharath and Aishwarya Sundaram and Jyothi Bhat and Vasan K. Sambandamurthy and Christofer Bj{\"o}rkelid and T. A. Jones and Kaveri S Das and Balachandra S Bandodkar and Krishnan Malolanarasimhan and Kakoli Mukherjee and Vasanthi Ramachandran},
  journal={Antimicrobial agents and chemotherapy},
  year={2014},
  volume={58 6},
  pages={3312-26}
}
Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenate, the first committed and rate-limiting step toward coenzyme A (CoA) biosynthesis. In our earlier reports, we had established that the type I isoform encoded by the coaA gene is an essential pantothenate kinase in Mycobacterium tuberculosis, and this vital information was then exploited to screen large libraries for identification of mechanistically different classes of PanK inhibitors. The present report summarizes the… CONTINUE READING

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