Assessment of Intrathecal Free Light Chain Synthesis: Comparison of Different Quantitative Methods with the Detection of Oligoclonal Free Light Chains by Isoelectric Focusing and Affinity-Mediated Immunoblotting

@inproceedings{Zeman2016AssessmentOI,
  title={Assessment of Intrathecal Free Light Chain Synthesis: Comparison of Different Quantitative Methods with the Detection of Oligoclonal Free Light Chains by Isoelectric Focusing and Affinity-Mediated Immunoblotting},
  author={David Zeman and Pavl{\'i}na Ku{\vs}nierov{\'a} and Zdeněk {\vS}vagera and Franti{\vs}ek V{\vs}iansk{\'y} and Monika Byrtusov{\'a} and MUDr.Pavel Hrad{\'i}lek and Barbora Kurkov{\'a} and Olga Zapletalov{\'a} and Vladimı́r Barto{\vs}},
  booktitle={PloS one},
  year={2016}
}
OBJECTIVES We aimed to compare various methods for free light chain (fLC) quantitation in cerebrospinal fluid (CSF) and serum and to determine whether quantitative CSF measurements could reliably predict intrathecal fLC synthesis. In addition, we wished to determine the relationship between free kappa and free lambda light chain concentrations in CSF and serum in various disease groups. METHODS We analysed 166 paired CSF and serum samples by at least one of the following methods: turbidimetry… CONTINUE READING
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