Assessment of IgE-receptor function through measurement of hydrolysis of membrane inositol phospholipids. New insights on the phenomena of biphasic antigen concentration-response curves and desensitization.

@article{Maeyama1988AssessmentOI,
  title={Assessment of IgE-receptor function through measurement of hydrolysis of membrane inositol phospholipids. New insights on the phenomena of biphasic antigen concentration-response curves and desensitization.},
  author={Kazutaka Maeyama and R J Hohman and H. Sheik Jahabar Ali and J. R. Cunha-Melo and Michael A. Beaven},
  journal={Journal of immunology},
  year={1988},
  volume={140 11},
  pages={3919-27}
}
Previous studies have shown that hydrolysis of membrane inositol phospholipids in rat basophilic leukemia (RBL-2H3) cells depended on the rate and extent of the aggregation of receptors of IgE. This response was used as an experimental probe to study the role of IgE receptors in initiating stimulatory and inhibitory processes within the cell. The response was amplified markedly by increasing the concentration of external Ca2+ from 0 to 1 mM, but the concentration required to support half… CONTINUE READING
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