Assessment of Herpesvirus saimiri as a potential human gene therapy vector.

@article{Stevenson1999AssessmentOH,
  title={Assessment of Herpesvirus saimiri as a potential human gene therapy vector.},
  author={Alex J. Stevenson and Matt Cooper and Jodianne Griffiths and Pamela C. Gibson and Adrian Whitehouse and Ella Fung Jones and Alexander F. Markham and S. E. Kinsey and Diana M Meredith},
  journal={Journal of medical virology},
  year={1999},
  volume={57 3},
  pages={269-77}
}
Herpesvirus saimiri has characteristics that make it amenable to development as a gene therapy vector. The viral genome is thought to be capable of accommodating large quantities of heterologous DNA while the virus itself can infect many different cell types. Virus infection has been shown in many cases to be persistent by virtue of episomal maintenance in the target cell. In this article we examine the ability of nonselectable recombinant viruses expressing the beta-galactosidase gene product… CONTINUE READING