Assessment of Her-1, Her-2, And Her-3 expression and Her-2 amplification in advanced stage ovarian carcinoma.

@article{Lee2005AssessmentOH,
  title={Assessment of Her-1, Her-2, And Her-3 expression and Her-2 amplification in advanced stage ovarian carcinoma.},
  author={Cheng-Han Lee and David G. Huntsman and Maggie C U Cheang and Robin L Parker and Lindsay Brown and Paul Hoskins and Dianne Miller and Cyril Blake Gilks},
  journal={International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists},
  year={2005},
  volume={24 2},
  pages={147-52}
}
The human epidermal growth factor receptor (Her) family of receptor tyrosine kinases includes Her-1, Her-2, and Her-3. The overexpression of Her-1 and Her-2 have been reported previously in surface epithelial ovarian cancer. Although up to one-third of ovarian carcinomas have been found to have amplification or overexpression of Her-2, responses to trastuzumab therapy in these patients have been disappointing. In this study, we examined Her-1, Her-2, and Her- 3 protein expression as well as the… CONTINUE READING

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