Assessment of HER-2 status in pancreatic adenocarcinoma: correlation of immunohistochemistry, quantitative real-time RT-PCR, and FISH with aneuploidy and survival.

@article{Saxby2005AssessmentOH,
  title={Assessment of HER-2 status in pancreatic adenocarcinoma: correlation of immunohistochemistry, quantitative real-time RT-PCR, and FISH with aneuploidy and survival.},
  author={Alexander J Saxby and A. C. Nielsen and Christopher J Scarlett and Adele Clarkson and Adrienne Morey and Anthony J Gill and Ross C. Smith},
  journal={The American journal of surgical pathology},
  year={2005},
  volume={29 9},
  pages={1125-34}
}
HER-2 is a transmembrane growth factor receptor recognized in overexpression as an independent adverse prognostic factor in several cancers. This study measured HER-2 overexpression in pancreatic adenocarcinoma at the genetic, transcriptional, and translational level. Expression was gauged with regard to stage, grade, and survival. Pancreatic adenocarcinoma samples (n = 30) were analyzed with immunohistochemical labeling for HER-2 protein, Quantitative real-time reverse transcriptase polymerase… CONTINUE READING
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