Assessment of Glial Scar, Tissue Sparing, Behavioral Recovery and Axonal Regeneration following Acute Transplantation of Genetically Modified Human Umbilical Cord Blood Cells in a Rat Model of Spinal Cord Contusion

@inproceedings{Mukhamedshina2016AssessmentOG,
  title={Assessment of Glial Scar, Tissue Sparing, Behavioral Recovery and Axonal Regeneration following Acute Transplantation of Genetically Modified Human Umbilical Cord Blood Cells in a Rat Model of Spinal Cord Contusion},
  author={Yana O Mukhamedshina and Ekaterina Evgenevna Garanina and Galina A. Masgutova and Luisa R. Galieva and Elvira R. Sanatova and Yurii A. Chelyshev and Albert A Rizvanov},
  booktitle={PloS one},
  year={2016}
}
OBJECTIVE AND METHODS This study investigated the potential for protective effects of human umbilical cord blood mononuclear cells (UCB-MCs) genetically modified with the VEGF and GNDF genes on contusion spinal cord injury (SCI) in rats. An adenoviral vector was constructed for targeted delivery of VEGF and GDNF to UCB-MCs. Using a rat contusion SCI model we examined the efficacy of the construct on tissue sparing, glial scar severity, the extent of axonal regeneration, recovery of motor… CONTINUE READING