Assessment of GABAA benzodiazepine receptor (GBzR) sensitivity in patients on benzodiazepines

@article{Potokar1999AssessmentOG,
  title={Assessment of GABAA benzodiazepine receptor (GBzR) sensitivity in patients on benzodiazepines},
  author={John P. Potokar and Nick Coupland and S. J. Wilson and Ann S. Rich and David J. Nutt},
  journal={Psychopharmacology},
  year={1999},
  volume={146},
  pages={180-184}
}
Abstract  Objectives: To measure GABAA benzodiazepine receptor sensitivity in patients taking benzodiazepines and compare with matched controls. Methods: Seven patients who were on prescribed benzodiazepines for an anxiety disorder or insomnia were recruited from general practice and an adult mental health service outpatient clinic. They were matched with seven volunteers. All subjects received an intravenous injection of midazolam 50 µg/kg in 10 ml normal saline over 10 min. Objective… Expand
PHARMACOLOGY AND CELL METABOLISM Assessment of GABAA Benzodiazepine Receptor (GBzR) Sensitivity in Patients with Alcohol Dependence
Aim: The aim of this study was to measure GABAA benzodiazepine receptor (GBzR) sensitivity in alcohol-dependent patients and compare with matched non-dependent drinkers. Methods: Nine abstinentExpand
Assessment of GABAA benzodiazepine receptor (GBzR) sensitivity in patients with alcohol dependence.
TLDR
The hypothesis that patients with alcohol dependence would have less slowing of their eye movements in response to this challenge, reflecting reducedGBzR sensitivity, was not confirmed and this could mean that GBzR function returns to normal with abstinence, or that this paradigm is unable to measure the subtle subtype-specific changes in GBzr sensitivity that occur following dependent alcohol use. Expand
Side effects of treatment with benzodiazepines.
TLDR
Previous investigations showed that treatment with benzodiazepines may induce anterograde amnesia, and previous studies confirmed occurrence of physical dependence in high percentage of patients in long term treatment with Benzodiazepine at therapeutic dosages. Expand
Saccadic Eye Velocity after Selective GABAergic Treatment with Tiagabine in Healthy Volunteers
TLDR
Treatment with tiagabine had no significant effect on SEV and saccade amplitude and the subchronic tolerance effects or the different site of action on the GABAA/BZD receptor complex may account for this deviating profile. Expand
Clinical uses of benzodiazepines. Focus on: benzodiazepines and anxiety disorders
TLDR
Benzodiazepines have proven very effective in panic disorder, generalized anxiety and, even if to a lower degree, in social phobia, and role in obsessive compulsive disorder and post traumatic stress disorder is not as strong but these medications may be useful for several patients with those diseases. Expand
GABAAbenzodiazepine receptor (GBzR) sensitivity: test–retest reliability in normal volunteers
TLDR
This work has developed a paradigm for assessing GBzR sensitivity using slowing of saccadic eye movements in response to intravenous midazolam to assess patients with some forms of anxiety disorder. Expand
Neonatal Adaptation Issues After Maternal Exposure to Prescription Drugs: Withdrawal Syndromes and Residual Pharmacological Effects
TLDR
This narrative review is aimed at the description of drugs and drug classes for which licit maternal use in the predelivery period has been associated with neonatal non-teratogenic disorders, mainly for substances used illicitly for recreational purposes. Expand
Alcohol misuse and anxiety : prevalence and incidence
The relationship between anxiety disorders and substance misuse is intimate. Here we concentrate on alcohol, although for completeness we also briefly mention other substances taken for anxietyExpand
Vergiftungen mit psychotropen Substanzen
TLDR
For treatment of benzodiazepine and opioid intoxication, flumazenil and naloxone are used as specific antagonists and β‑Blocker sind bei Intoxikationen mit Kokain and Amphetaminderivaten zu vermeiden. Expand
An anxiety-like phenotype in mice selectively bred for aggression
TLDR
Reductions in the alpha(2) subunit protein in selected brain regions may underlie the anxiety and aggressive phenotype of NC900 mice, suggesting that anxiety and aggression are comorbid in certain psychiatric conditions. Expand
...
1
2
...

References

SHOWING 1-10 OF 17 REFERENCES
Benzodiazepine Sensitivity in Panic Disorder: Effects of Chronic Alprazolam Treatment
TLDR
Compared with untreated patients, alprazolam-treated patients displayed significantly less diazepam-induced change in peak saccadic velocity, saccade latency, growth hormone secretion, memory, and self-rated levels of sedation, suggesting that overall group differences were at least partially attributable to the development of tolerance to selected benzodiazepine effects with chronic alpazolam treatment. Expand
Chronic benzodiazepine treatment decreases postsynaptic GABA sensitivity
TLDR
Electrophysiological evidence for decreased postsynaptic sensitivity to GABA following chronic benzodiazepine administration is presented as measured by the direct iontophoretic application of GABA and serotonin onto serotonergic cells in the midbrain dorsal raphe nucleus (DRN), known to receive GABAergic input. Expand
Pharmacology of saccadic eye movements in man. 1. Effects of the benzodiazepine receptor ligands midazolam and flumazenil.
TLDR
Changes in saccade variables and sedation ratings were significantly correlated, and also correlated with plasma midazolam concentrations, and appeared to be a sensitive means of assessing benzodiazepine receptor function in man. Expand
Reduced benzodiazepine sensitivity in patients with panic disorder: comparison with patients with obsessive-compulsive disorder and normal subjects.
TLDR
Patients with panic disorder are less sensitive than comparison subjects to diazepam, and this difference is not an artifact of resistance to sedation, it may reflect a more nonspecific aspect of anxiety disorders. Expand
Flumazenil provocation of panic attacks. Evidence for altered benzodiazepine receptor sensitivity in panic disorder.
TLDR
Subjective anxiety responses after flumazenil infusion were significantly higher in the patient group with panic disorder than in the controls, and eight patients withpanic disorder but no controls had panic attacks. Expand
Reduced benzodiazepine sensitivity in panic disorder.
TLDR
It is suggested that panic disorder is associated with functional subsensitivity of the gamma-aminobutyric acid-benzodiazepine supramolecular complex in brain-stem areas controlling saccadic eye movements. Expand
Decreased GABAA receptor subunit mRNA concentrations following chronic lorazepam administration
TLDR
Alterations in mRNAs in cortex occur after the development of tolerance and receptor downregulation in this model and no significant alterations were observed for either subunit mRNA in hippocampus or cerebellum over the same time course. Expand
Chronic benzodiazepine treatment increases the effects of the inverse agonist FG7142
TLDR
A schedule of treatment with the benzodiazepine, flurazepam, in mice for 7 days caused a significant enhancement of the convulsive effects of the partial inverse agonist FG7142, although this compound does not cause convulsions in normal mice of the strain used. Expand
Reduced diazepam binding following chronic benzodiazepine treatment.
TLDR
It is concluded that chronic benzodiazepine treatment caused an apparent decrease in the number of specific binding sites in rat cortex after 7–10 days of twice daily injection of a large dose of flurazepam. Expand
Rapid induction of lorazepam dependence and reversal with flumazenil.
TLDR
The present study demonstrates the rapid development of tolerance and dependence to lorazepam, defines its pharmacology in more detail, and shows that it may be rapidly reversed by treatment with the benzodiazepine antagonist flumazenil. Expand
...
1
2
...