Assessment of Dosing Impact on Intra-Individual Variability in Estimation of Parameters for Basic Indirect Response Models

Abstract

The application of D-optimization and the assessment of bias and precision of parameter estimates for four basic pharmacodynamic (PD) indirect response (IDR) models for ascending doses was examined using simulated data. While D-optimization provided four sampling times, each IDR model was used to generate eight data points per dose level. The PD parameters… (More)
DOI: 10.1007/s10928-006-9028-y

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