Assessment of DNA oxidation by nitroheterocyclic compounds using cultured YAC-1 cells

Abstract

Contradictory results have been published on the DNA damaging properties of the nitroheterocyclic compounds metronidazole and nitrofurantoin, antimicrobial agents widely used in human and veterinary medicine. In order to further study whether their interaction with cellular DNA is linked to the generation of reactive oxygen species we investigated the… (More)

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