Assessment of Amino Acid/Drug Transporters for Renal Transport of [18F]Fluciclovine (anti-[18F]FACBC) in Vitro

Abstract

[18F]Fluciclovine (trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid; anti-[18F]FACBC), a positron emission tomography tracer used for the diagnosis of recurrent prostate cancer, is transported via amino acid transporters (AATs) with high affinity (Km: 97-230 μM). However, the mechanism underlying urinary excretion is unknown. In this study, we… (More)

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Cite this paper

@inproceedings{Ono2016AssessmentOA, title={Assessment of Amino Acid/Drug Transporters for Renal Transport of [18F]Fluciclovine (anti-[18F]FACBC) in Vitro}, author={Masahiro Ono and Atsumi Baden and Hiroyuki Okudaira and Masato Kobayashi and Keiichi Kawai and Shuntaro Oka and Hirokatsu Yoshimura}, booktitle={International journal of molecular sciences}, year={2016} }