Assessment and implication of the allergic sensitivity to a single dose of recombinant human hyaluronidase injection: a double-blind, placebo-controlled clinical trial.

@article{Yocum2007AssessmentAI,
  title={Assessment and implication of the allergic sensitivity to a single dose of recombinant human hyaluronidase injection: a double-blind, placebo-controlled clinical trial.},
  author={Richard C. Yocum and Don Kennard and Linda S Heiner},
  journal={Journal of infusion nursing : the official publication of the Infusion Nurses Society},
  year={2007},
  volume={30 5},
  pages={
          293-9
        }
}
Animal-extracted injectable hyaluronidases have been used safely for more than 50 years to increase the dispersion and absorption of coadministered drugs and fluids; however, concern still exists about the allergic and immunological risks of these products. Hylenex recombinant, a novel formulation of recombinant human hyaluronidase, has been developed as an alternative to these animal-derived hyaluronidases. Because recombinant human hyaluronidase is a human (nonforeign) protein manufactured… CONTINUE READING

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