Assessing tumor angiogenesis using macromolecular MR imaging contrast media.

  title={Assessing tumor angiogenesis using macromolecular MR imaging contrast media.},
  author={Robert C. Brasch and Cuong D Pham and David Shames and T. P. Pradeepa Roberts and K van Dijke and Nicholas van Bruggen and Jeffrey D. Mann and Susanne Ostrowitzki and Oksana Melnyk},
  journal={Journal of magnetic resonance imaging : JMRI},
  volume={7 1},
MRI enhanced with a macromolecular contrast medium (MMCM) has previously been shown to estimate tumor microvascular characteristics that correlate closely with histologic microvascular density, an established surrogate of tumor angiogenesis. A similar MMCM-enhanced MRI technique has now been used to investigate the acute tumor microvascular effects of antibody-mediated inhibition of vascular endothelial growth factor (VEGF), a well-studied and potent angiogenesis stimulator. Athymic rats… CONTINUE READING


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