Assessing the use of known mutagens to calibrate the Salmonella typhimurium mutagenicity assay: II. With exogenous activation.

@article{Claxton1991AssessingTU,
  title={Assessing the use of known mutagens to calibrate the Salmonella typhimurium mutagenicity assay: II. With exogenous activation.},
  author={Larry D. Claxton and Virginia S. Houk and James R. Warner and Lawrence E. Myers and Terence J. Hughes},
  journal={Mutation research},
  year={1991},
  volume={253 2},
  pages={149-59}
}
In order to determine the usefulness of selected chemicals as potential reference materials for calibrating the Salmonella assay, two laboratories tested a series of Salmonella mutagens that require exogenous activation. When the variance for individual substances within a bioassay is sufficiently low and the rankings of those substances are of acceptable consistency, they can later be evaluated for use as standard control compounds, as audit materials, and as standard reference materials for… CONTINUE READING

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