Assessing the survival of transgenic plant DNA in the human gastrointestinal tract

@article{Netherwood2004AssessingTS,
  title={Assessing the survival of transgenic plant DNA in the human gastrointestinal tract},
  author={Trudy Netherwood and Susana Mar{\'i}a Mart{\'i}n-Or{\'u}e and Anthony G. O'donnell and Sally Gockling and Julia Graham and John Cummings Mathers and Harry J. Gilbert},
  journal={Nature Biotechnology},
  year={2004},
  volume={22},
  pages={204-209}
}
The inclusion of genetically modified (GM) plants in the human diet has raised concerns about the possible transfer of transgenes from GM plants to intestinal microflora and enterocytes. The persistence in the human gut of DNA from dietary GM plants is unknown. Here we study the survival of the transgene epsps from GM soya in the small intestine of human ileostomists (i.e., individuals in which the terminal ileum is resected and digesta are diverted from the body via a stoma to a colostomy bag… 

The Stability and Degradation of Dietary DNA in the Gastrointestinal Tract of Mammals: Implications for Horizontal Gene Transfer and the Biosafety of GMOs

Despite the ability of several bacterial species to acquire external DNA by natural transformation, in vivo transfer of dietary DNA to bacteria in the intestine has not been detected in the few experimental studies conducted so far.

Assessing the Transfer of Genetically Modified DNA from Feed to Animal Tissues

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Evaluation of the possibility of horizontal gene transfer and accumulation of transgenic DNA from the diet in the bodies of rats

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Addressing the issue of horizontal gene transfer from a diet containing genetically modified components into rat tissues

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Horizontal transfer of antibiotic resistance genes into microflora and blood cells in rats fed on GM-diet

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Addressing concerns over the fate of DNA derived from genetically modified food in the human body: A review.

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Uptake and clearance of dietary DNA in the intestine of Atlantic salmon (Salmo salar L.) fed conventional or genetically modified soybeans

The results show that the salmon intestine is able to take up dietary plant DNA shortly after feed intake and that one of the factors affecting uptake and clearance of nucleic acids in the various intestinal segments are the feeding status of the fish.

Digestive fate of transgenic DNA and protein in livestock tissues fed genetically modified feed ingredients: A review

Findings from this study indicated that transgenic DNA is not completely degraded during feed processing and digestion and that DNA fragments could be detected by well-established detection methods such as PCR or qPCR in a number of organs and tissues of livestock animals.

Detection of transgenic and endogenous plant DNA in digesta and tissues of sheep and pigs fed Roundup Ready canola meal.

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