Assessing the stability of alanine-based helices by conformer-selective IR spectroscopy.

@article{Hoffmann2016AssessingTS,
  title={Assessing the stability of alanine-based helices by conformer-selective IR spectroscopy.},
  author={Waldemar Hoffmann and Mateusz Marianski and Stephan Warnke and Jongcheol Seo and Carsten Baldauf and Gert von Helden and Kevin Pagel},
  journal={Physical chemistry chemical physics : PCCP},
  year={2016},
  volume={18 29},
  pages={
          19950-4
        }
}
Polyalanine based peptides that carry a lysine at the C-terminus ([Ac-AlanLys + H](+)) are known to form α-helices in the gas phase. Three factors contribute to the stability of these helices: (i) the interaction between the helix macro dipole and the charge, (ii) the capping of dangling C[double bond, length as m-dash]O groups by lysine and (iii) the cooperative hydrogen bond network. In previous studies, the influence of the interaction between the helix dipole and the charge as well as the… CONTINUE READING
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