Assessing the sensitivity of diffusion MRI to detect neuronal activity directly.

@article{Bai2016AssessingTS,
  title={Assessing the sensitivity of diffusion MRI to detect neuronal activity directly.},
  author={Ruiliang Bai and Craig V. Stewart and Dietmar Plenz and Peter J. Basser},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 12},
  pages={E1728-37}
}
Functional MRI (fMRI) is widely used to study brain function in the neurosciences. Unfortunately, conventional fMRI only indirectly assesses neuronal activity via hemodynamic coupling. Diffusion fMRI was proposed as a more direct and accurate fMRI method to detect neuronal activity, yet confirmative findings have proven difficult to obtain. Given that the underlying relation between tissue water diffusion changes and neuronal activity remains unclear, the rationale for using diffusion MRI to… CONTINUE READING