Assessing the physiological concentration and targets of nitric oxide in brain tissue.

@article{Hall2008AssessingTP,
  title={Assessing the physiological concentration and targets of nitric oxide in brain tissue.},
  author={Catherine N Hall and David Attwell},
  journal={The Journal of physiology},
  year={2008},
  volume={586 15},
  pages={3597-615}
}
Low nanomolar concentrations of nitric oxide activate guanylyl cyclase to produce cGMP, which has diverse physiological effects. Higher concentrations inhibit mitochondrial respiration at cytochrome c oxidase and this has been proposed to be important physiologically, increasing oxygen permeation into tissue (by reducing the oxygen use of cells near blood vessels), activating AMP kinase, and regulating the relationship between cerebral blood flow and oxygen use. It is unclear, however, whether… CONTINUE READING

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