Assessing the mechanism of metabolism-dependent valproic acid-induced in vitro cytotoxicity.

@article{Tabatabaei1999AssessingTM,
  title={Assessing the mechanism of metabolism-dependent valproic acid-induced in vitro cytotoxicity.},
  author={Asghar Tabatabaei and Robert L. Thies and Frank S. Abbott},
  journal={Chemical research in toxicology},
  year={1999},
  volume={12 4},
  pages={323-30}
}
This study was designed to distinguish and evaluate the contribution of reactive metabolite and reactive oxygen species as the mechanism of metabolism-dependent valproic acid-induced in vitro cytotoxicity. The involvement of reactive oxygen species in the mechanism of in vitro cytotoxicity was examined by the addition of a series of antioxidant enzymes and iron chelators to the reaction mixture. Addition of catalase to the reaction mixture resulted in a complete prevention of valproic acid… CONTINUE READING
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