Assessing the limits of restraint-based 3D modeling of genomes and genomic domains

  title={Assessing the limits of restraint-based 3D modeling of genomes and genomic domains},
  author={Marie Trussart and François Serra and Davide Ba{\`u} and Ivan Junier and Luis J Serrano and Marc A. Mart{\'i}-Renom},
  booktitle={Nucleic acids research},
Restraint-based modeling of genomes has been recently explored with the advent of Chromosome Conformation Capture (3C-based) experiments. We previously developed a reconstruction method to resolve the 3D architecture of both prokaryotic and eukaryotic genomes using 3C-based data. These models were congruent with fluorescent imaging validation. However, the limits of such methods have not systematically been assessed. Here we propose the first evaluation of a mean-field restraint-based… CONTINUE READING
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