Assessing the introduction of universal human papillomavirus vaccination for preadolescent girls in The Netherlands.

Abstract

A persistent infection with human papillomavirus (HPV) is a prerequisite for the development of cervical cancer. Clinical trials with HPV-vaccines have been very successful in preventing persistent HPV16/18 infections, the two most oncogenic HPV-genotypes. We assessed the introduction of universal HPV-vaccination for preadolescent girls in the Dutch National Immunization Programme. Long-term vaccine efficacy, the need and extent of a catch-up programme for young women, and the impact of vaccination on the cervical cancer screening programme are major unresolved issues. Preliminary conservative estimates (80% vaccine efficacy and no effects on the screening programme, transmission rate, non-cervical cancer incidence, and cross protection) predict an acceptable cost-effectiveness ratio for universal vaccination of preadolescent girls.

Extracted Key Phrases

6 Figures and Tables

Statistics

010202008200920102011201220132014201520162017
Citations per Year

53 Citations

Semantic Scholar estimates that this publication has 53 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Boot2007AssessingTI, title={Assessing the introduction of universal human papillomavirus vaccination for preadolescent girls in The Netherlands.}, author={Hein J. Boot and Iris Wallenburg and Hester E de Melker and Marie-Jos{\'e} M Mangen and Annette A. M. Gerritsen and Nicoline van der Maas and Johannes Berkhof and C. J. L. M. Meijer and Tjeerd G. Kimman}, journal={Vaccine}, year={2007}, volume={25 33}, pages={6245-56} }