Assessing the initiation of cocaine self-administration in humans during abstinence: effects of dose, alternative reinforcement, and priming


Impaired ability to refrain from initiating cocaine-taking is a central feature of cocaine dependence and an important target for behavioral and pharmacological interventions. One potential trigger of cocaine-taking is exposure to cocaine (i.e. priming). Here, we report a model of human cocaine self-administration that quantifies the ability to refrain from… (More)
DOI: 10.1007/s00213-003-1655-z


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