Assessing the impact of lentiviral vector integration on splicing of cellular genes at the genome-wide level

Abstract

Oncogenesis induced by insertional mutagenesis with gene therapy vectors occurs mainly by activation of proto-oncogenes found at or nearby the insertion site. This activation often occurs by an enhancer-mediated mechanism or by a process of splicing capture which generates chimeric transcripts comprising portions of vector and cellular mRNAs. Although the… (More)
DOI: 10.1186/1742-4690-8-S2-O15

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Cite this paper

@inproceedings{Montini2011AssessingTI, title={Assessing the impact of lentiviral vector integration on splicing of cellular genes at the genome-wide level}, author={Eugenio Montini and Jacopo Sgualdino and Daniela Cesana and Fabrizio Benedicenti and Stefania Merella and Simone Leo and Gianluigi Zanetti and Luigi Naldini}, booktitle={Retrovirology}, year={2011} }