Assessing the genetic architecture of epithelial ovarian cancer histological subtypes

  title={Assessing the genetic architecture of epithelial ovarian cancer histological subtypes},
  author={Gabriel Cuellar-Partida and Yi Lu and Suzanne C. Dixon and Peter A. Fasching and Alexander Hein and Stefanie Burghaus and Matthias W. Beckmann and Diether Lambrechts and Els Van Nieuwenhuysen and Ignace Vergote and Adriaan Vanderstichele and Jennifer A Doherty and Mary Anne Rossing and Jenny Chang-Claude and Anja Rudolph and Shan Wang-gohrke and Marc T. Goodman and Natalia Bogdanova and Thilo D{\"o}rk and Matthias D{\"u}rst and Peter Hillemanns and I B Runnebaum and Natalia N. Antonenkova and Ralf Butzow and Arto Leminen and Heli Nevanlinna and L M Pelttari and Robert Edwards and Joseph Leo Kelley and Francesmary Modugno and Kirsten B Moysich and Roberta B. Ness and Rikki Cannioto and Estrid V. S. H\ogdall and Claus Kim H\ogdall and Allan Jensen and Graham G. Giles and Fiona Bruinsma and Susanne Kr{\"u}ger Kjaer and Michelle A. T. Hildebrandt and Dong Liang and Karen H. Lu and X ianchao Wu and Maria Bisogna and Fanny Dao and Douglas A. Levine and Daniel W Cramer and Kathryn L. Terry and Shelley S Tworoger and Meir Stampfer and Stacey Missmer and Line Bjorge and Helga Birgitte Salvesen and Reidun Kristin Kopperud and Katharina Bischof and Katja K. H. Aben and Lambertus A. L. M. Kiemeney and Leon F. A. G. Massuger and Angela Brooks-Wilson and Sara H. Olson and Valerie A McGuire and Joseph Rothstein and Weiva Sieh and Alice S. Whittemore and Linda Sue Cook and Nhu D. Le and C. Blake Gilks and Jacek Gronwald and Anna Jakubowska and Jan A. Lubiński and Tomasz Kluz and Honglin Song and Jonathan P. Tyrer and Nicolas Wentzensen and Louise A Brinton and B Trabert and Jolanta Lissowska and John R McLaughlin and Steven A Narod and Catherine M. Phelan and Hoda Anton-Culver and Argyrios Ziogas and Diana Eccles and Ian G. Campbell and Simon A. Gayther and Aleksandra Gentry-Maharaj and Usha Menon and Susan J Ramus and Anna H Wu and Agnieszka Dansonka-Mieszkowska and Jolanta Kupryjańczyk and Agnieszka Timorek and Lukasz Michal Szafron and Julie M Cunningham and Brooke L. Fridley and Stacey J Winham and Elisa V. Bandera and Elizabeth M Poole and Terry K. Morgan and Ellen L. Goode and Joellen Martha Schildkraut and Celeste Leigh Pearce and Andrew Berchuck and Paul P. D. Pharoah and Penelope M Webb and Georgia Chenevix-Trench and Harvey A. Risch and Stuart Macgregor},
  journal={Human Genetics},
Epithelial ovarian cancer (EOC) is one of the deadliest common cancers. The five most common types of disease are high-grade and low-grade serous, endometrioid, mucinous and clear cell carcinoma. Each of these subtypes present distinct molecular pathogeneses and sensitivities to treatments. Recent studies show that certain genetic variants confer susceptibility to all subtypes while other variants are subtype-specific. Here, we perform an extensive analysis of the genetic architecture of EOC… CONTINUE READING