Assessing the flexibility of intermediate filaments by atomic force microscopy.

  title={Assessing the flexibility of intermediate filaments by atomic force microscopy.},
  author={Norbert M{\"u}cke and Laurent Kreplak and Robert Kirmse and Tatjana Wedig and Harald Herrmann and Ueli Aebi and J{\"o}rg Langowski},
  journal={Journal of molecular biology},
  volume={335 5},
Eukaryotic cells contain three cytoskeletal filament systems that exhibit very distinct assembly properties, supramolecular architectures, dynamic behaviour and mechanical properties. Microtubules and microfilaments are relatively stiff polar structures whose assembly is modulated by the state of hydrolysis of the bound nucleotide. In contrast, intermediate filaments (IFs) are more flexible apolar structures assembled from a approximately 45 nm long coiled-coil dimer as the elementary building… CONTINUE READING
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