Assessing the emetic potential of PDE4 inhibitors in rats.

@article{Robichaud2002AssessingTE,
  title={Assessing the emetic potential of PDE4 inhibitors in rats.},
  author={Annette Robichaud and Chantal Savoie and Panagiota B Stamatiou and Nicholas Lachance and Paul Jolicoeur and R Rasori and C C Chan},
  journal={British journal of pharmacology},
  year={2002},
  volume={135 1},
  pages={113-8}
}
1. Type 4 phosphodiesterase (PDE4) inhibitors mimic the pharmacological actions of alpha(2)-adrenoceptor antagonists. This has been postulated as the mechanism by which PDE4 inhibitors induce emesis and was also demonstrated by their ability to reverse xylazine/ketamine-induced anaesthesia. We further characterized this latter effect since it appears to reflect the emetic potential of PDE4 inhibitors. 2. Selective inhibitors of PDE 1, 2, 3, 4 and 5 were studied in rats, on the duration of… CONTINUE READING

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