Assessing the emetic potential of PDE4 inhibitors in rats.

  title={Assessing the emetic potential of PDE4 inhibitors in rats.},
  author={Annette Robichaud and Chantal Savoie and Panagiota B Stamatiou and Nicholas Lachance and Paul Jolicoeur and R Rasori and C C Chan},
  journal={British journal of pharmacology},
  volume={135 1},
1. Type 4 phosphodiesterase (PDE4) inhibitors mimic the pharmacological actions of alpha(2)-adrenoceptor antagonists. This has been postulated as the mechanism by which PDE4 inhibitors induce emesis and was also demonstrated by their ability to reverse xylazine/ketamine-induced anaesthesia. We further characterized this latter effect since it appears to reflect the emetic potential of PDE4 inhibitors. 2. Selective inhibitors of PDE 1, 2, 3, 4 and 5 were studied in rats, on the duration of… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 43 extracted citations

Small molecule allosteric modulators of phosphodiesterase 4.

Handbook of experimental pharmacology • 2011
View 4 Excerpts
Highly Influenced

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

Behavioural Brain Research • 2016
View 4 Excerpts
Highly Influenced

Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2011
View 8 Excerpts
Highly Influenced

PDE4 inhibitors: current status.

British journal of pharmacology • 2008
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…