Assessing the collective disease association of multiple genomic loci

  title={Assessing the collective disease association of multiple genomic loci},
  author={Marzieh Ayati and Mehmet Koyut{\"u}rk},
  journal={Proceedings of the 6th ACM Conference on Bioinformatics, Computational Biology and Health Informatics},
  • M. Ayati, Mehmet Koyutürk
  • Published 9 September 2015
  • Biology
  • Proceedings of the 6th ACM Conference on Bioinformatics, Computational Biology and Health Informatics
Genome-wide association studies (GWAS) facilitate large-scale identification of genomic variants that are associated with complex traits. However, susceptibility loci identified by GWAS so far generally account for a limited fraction of the genotypic variation in patient populations. Predictive models based on identified loci also have modest success in risk assessment and therefore are of limited practical use. In this paper, we propose a new method to identify sets of loci that are… 
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