Assessing the Association between Trends in a Biomarker and Risk of Event with an Application in Pediatric Hiv/aids.

Abstract

We present a new joint longitudinal and survival model aimed at estimating the association between the risk of an event and the change in and history of a biomarker that is repeatedly measured over time. We use cubic B-splines models for the longitudinal component that lend themselves to straight-forward formulations of the slope and integral of the… (More)

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Cite this paper

@article{Brown2009AssessingTA, title={Assessing the Association between Trends in a Biomarker and Risk of Event with an Application in Pediatric Hiv/aids.}, author={Elizabeth R. Brown}, journal={The annals of applied statistics}, year={2009}, volume={3 3}, pages={1163-1182} }