Assessing the Accuracy and Power of Population Genetic Inference from Low-Pass Next-Generation Sequencing Data

@inproceedings{Crawford2012AssessingTA,
  title={Assessing the Accuracy and Power of Population Genetic Inference from Low-Pass Next-Generation Sequencing Data},
  author={Jacob E. Crawford and Brian P Lazzaro},
  booktitle={Front. Gene.},
  year={2012}
}
Next-generation sequencing (NGS) technologies have made it possible to address population genetic questions in almost any system, but high error rates associated with such data can introduce significant biases into downstream analyses, necessitating careful experimental design and interpretation in studies based on short-read sequencing. Exploration of population genetic analyses based on NGS has revealed some of the potential biases, but previous work has emphasized parameters relevant to… CONTINUE READING

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