Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test

  title={Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test},
  author={John F. Cryan and Rita J. Valentino and Irwin Lucki},
  journal={Neuroscience \& Biobehavioral Reviews},
Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats
Findings suggest that 5-HT6 receptor agonists may represent a new class of potential antidepressant and anxiolytic compounds and could possess a number of advantages over currently available treatments, including rapid onset of anxIOlytic efficacy.
Facilitating antidepressant-like actions of estrogens are mediated by 5-HT1A and estrogen receptors in the rat forced swimming test
The aim of the present work was to explore the participation of serotonin 1A receptors (5-HT1A) and estrogen receptors (ERs) in the antidepressant-like actions of E2, FLX or their combination in the FST, and to infer which neurotransmitter system is modulating the action of an antidepressant compound.
Effect of various classes of antidepressants in behavioral paradigms of despair
  • S. Kulkarni, A. Dhir
  • Psychology, Biology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2007
Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism
Observations are consistent with a role for 5-HT in mediating sustained antidepressant activity of ketamine in the FST, and molecular and cellular changes induced by ketamine may produce a rapid adaptation of 5- HT transmission which underlies the antidepressant response.
Active behaviours produced by antidepressants and opioids in the mouse tail suspension test.
The results show that at least two behaviourally distinct processes occur in the TST, highlighting the antidepressant-like effects of opioids evident in this test, and suggest that swinging and curling behaviours are mediated by enhanced monoamine and opioid neurotransmission, respectively.
Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment
The effects of antidepressants were augmented following chronic administration for 14 days, especially when given at low doses, suggesting that modifications of the FST can be used to examine the onset of action of antidepressant agents produced by long-term administration.
5-HT1A-receptor over-expressing mice: Genotype and sex dependent responses to antidepressants in the forced swim-test


Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test
Depletion of serotonin prevented the behavioral effects of the selective serotonin reuptake inhibitor fluoxetine in the rat FST, and depletion of serotonin had no impact on the behavior effects induced by the selective norepinephrine reptake inhibitor, desipramine.
Antidepressant-like behavioral effects of serotonin receptor agonists
Antidepressant behavioral effects by dual inhibition of monoamine reuptake in the rat forced swimming test
Combining certain doses of pharmacologically selective monoamine reuptake inhibitors, or the mixed reptake inhibitor venlafaxine, produced a pattern of mixed active behaviors in the FST that may reflect the activity of multiple neurotransmitters, especially the combination of enhanced 5-HT and DA activity.
Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants
This study demonstrated that distinct patterns of active behaviors are produced by antidepressants that selectively inhibit norepinephrine (NE) or serotonin (5-HT) uptake in the rat forced swimming test (FST), and showed that SSRIs are not false negatives in the FST.
Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression.
The results indicated that low doses of desipramine and fluoxetine produced different behavioral patterns in the FST, but only after chronic administration, which strengthens the validity of the F ST as a behavioral screen for antidepressant drugs with features similar to an animal model of depression.
Antidepressant-like activity of 5-HT1A agonists measured with the forced swim test
5-HT1A agonists may have antidepressant efficacy and act as a novel class of antidepressant drug in rats, and are producing their antidepressant-like effects through postsynaptic 5- HT1A receptors.
The forced swimming test as a model for core and component behavioral effects of antidepressant drugs.
  • I. Lucki
  • Psychology, Biology
    Behavioural pharmacology
  • 1997
The revised scoring of the forced swimming test corresponds to a behavioral test for antidepressant drugs that meet these criteria and should be sensitive to all antidepressant drugs and should also display multiple components that are sensitive to specific drug classes.
Behavioral studies of serotonin receptor agonists as antidepressant drugs.
Evidence is reviewed that the antidepressant activity may be due to the activation of postsynaptic 5-HT1A receptors, although 5- HT1A receptor agonists also activate somatodendritic autoreceptors which diminish the release of 4-HT, and evidence does not support the involvement of a common metabolite 1-PP in the antidepressants activity of 5-ht1Aceptor-selective azapirones.