Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test

@article{Cryan2005AssessingSU,
  title={Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test},
  author={John F. Cryan and Rita J. Valentino and Irwin Lucki},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2005},
  volume={29},
  pages={547-569}
}
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    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2007
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TLDR
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TLDR
The effects of antidepressants were augmented following chronic administration for 14 days, especially when given at low doses, suggesting that modifications of the FST can be used to examine the onset of action of antidepressant agents produced by long-term administration.
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References

SHOWING 1-10 OF 188 REFERENCES
Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test
TLDR
Depletion of serotonin prevented the behavioral effects of the selective serotonin reuptake inhibitor fluoxetine in the rat FST, and depletion of serotonin had no impact on the behavior effects induced by the selective norepinephrine reptake inhibitor, desipramine.
Antidepressant-like behavioral effects of serotonin receptor agonists
Antidepressant behavioral effects by dual inhibition of monoamine reuptake in the rat forced swimming test
TLDR
Combining certain doses of pharmacologically selective monoamine reuptake inhibitors, or the mixed reptake inhibitor venlafaxine, produced a pattern of mixed active behaviors in the FST that may reflect the activity of multiple neurotransmitters, especially the combination of enhanced 5-HT and DA activity.
Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants
TLDR
This study demonstrated that distinct patterns of active behaviors are produced by antidepressants that selectively inhibit norepinephrine (NE) or serotonin (5-HT) uptake in the rat forced swimming test (FST), and showed that SSRIs are not false negatives in the FST.
Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression.
TLDR
The results indicated that low doses of desipramine and fluoxetine produced different behavioral patterns in the FST, but only after chronic administration, which strengthens the validity of the F ST as a behavioral screen for antidepressant drugs with features similar to an animal model of depression.
Antidepressant-like activity of 5-HT1A agonists measured with the forced swim test
TLDR
5-HT1A agonists may have antidepressant efficacy and act as a novel class of antidepressant drug in rats, and are producing their antidepressant-like effects through postsynaptic 5- HT1A receptors.
The forced swimming test as a model for core and component behavioral effects of antidepressant drugs.
  • I. Lucki
  • Psychology, Biology
    Behavioural pharmacology
  • 1997
TLDR
The revised scoring of the forced swimming test corresponds to a behavioral test for antidepressant drugs that meet these criteria and should be sensitive to all antidepressant drugs and should also display multiple components that are sensitive to specific drug classes.
Behavioral studies of serotonin receptor agonists as antidepressant drugs.
TLDR
Evidence is reviewed that the antidepressant activity may be due to the activation of postsynaptic 5-HT1A receptors, although 5- HT1A receptor agonists also activate somatodendritic autoreceptors which diminish the release of 4-HT, and evidence does not support the involvement of a common metabolite 1-PP in the antidepressants activity of 5-ht1Aceptor-selective azapirones.
...
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