Assessing risks from data on other exposure routes. Possibilities and limitations of using toxicity data derived from one exposure route in assessing risks from other exposure routes.

@article{Sharratt1988AssessingRF,
  title={Assessing risks from data on other exposure routes. Possibilities and limitations of using toxicity data derived from one exposure route in assessing risks from other exposure routes.},
  author={Michael Sharratt},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={1988},
  volume={8 4},
  pages={399-407}
}
There is no simple and generally applicable way in which toxicity data derived from one route of exposure can be used to evaluate the effects of exposure by another route in the same species of animal or for risk assessment of another exposure route in man. Reliable predictions may be made in some cases where substances act systemically and have relatively long half-lives and where there are adequate data on toxicity by one route and on pharmacokinetics and metabolism by both routes… CONTINUE READING