Assessing post-stroke behavior in mouse models of focal ischemia.

  title={Assessing post-stroke behavior in mouse models of focal ischemia.},
  author={Mustafa Balkaya and Jan M Kr{\"o}ber and Andr{\'e} Rex and Matthias Endres},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={33 3},
Experimental treatment strategies and neuroprotective drugs that showed therapeutic promise in animal models of stroke have failed to produce beneficial effects in human stroke patients. The difficulty in translating preclinical findings to humans represents a major challenge in cerebrovascular research. The reasons behind this translational road block might be explained by a number of factors, including poor quality control in various stages of the research process, the validity of… CONTINUE READING