Assessing phage therapy against Pseudomonas aeruginosa using a Galleria mellonella infection model.

  title={Assessing phage therapy against Pseudomonas aeruginosa using a Galleria mellonella infection model.},
  author={Michael L. Beeton and Diana R Alves and Mark C. Enright and A Toby A Jenkins},
  journal={International journal of antimicrobial agents},
  volume={46 2},
The Galleria mellonella infection model was used to assess the in vivo efficacy of phage therapy against laboratory and clinical strains of Pseudomonas aeruginosa. In a first series of experiments, Galleria were infected with the laboratory strain P. aeruginosa PAO1 and were treated with varying multiplicity of infection (MOI) of phages either 2h post-infection (treatment) or 2h pre-infection (prevention) via injection into the haemolymph. To address the kinetics of infection, larvae were bled… CONTINUE READING


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