Assessing health effects of environmental contaminants by molecular markers. Studies on methylmercury and polychlorinated biphenyls as examples of translational research in environmental toxicology.

@article{Coccini2010AssessingHE,
  title={Assessing health effects of environmental contaminants by molecular markers. Studies on methylmercury and polychlorinated biphenyls as examples of translational research in environmental toxicology.},
  author={Teresa Coccini and Elisa Roda and Dimosthenis A. Sarigiannis and Luigi Manzo},
  journal={Giornale italiano di medicina del lavoro ed ergonomia},
  year={2010},
  volume={32 1},
  pages={5-12}
}
Evaluating the human effects of combinations of neurotoxicants is extremely difficult. Parallel studies correlating exposure parameters and "surrogate" indicators of neural cell function may represent a promising strategy. Molecular markers such as cholinergic muscarinic receptors (MRs) and monoamine oxidase activity (MAO-B) are expressed not only in brain but also in peripheral blood cells. Measurements of MRs and MAO-B in these easily accessible matrices can provide valuable information on… CONTINUE READING