Assessing gene-level translational control from ribosome profiling

@article{Olshen2013AssessingGT,
  title={Assessing gene-level translational control from ribosome profiling},
  author={Adam B. Olshen and Andrew C. Hsieh and Craig R. Stumpf and Richard A. Olshen and Davide Ruggero and Barry S. Taylor},
  journal={Bioinformatics},
  year={2013},
  volume={29 23},
  pages={2995-3002}
}
MOTIVATION The translational landscape of diverse cellular systems remains largely uncharacterized. A detailed understanding of the control of gene expression at the level of messenger RNA translation is vital to elucidating a systems-level view of complex molecular programs in the cell. Establishing the degree to which such post-transcriptional regulation can mediate specific phenotypes is similarly critical to elucidating the molecular pathogenesis of diseases such as cancer. Recently… CONTINUE READING
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