Assessing functional divergence in EF-1alpha and its paralogs in eukaryotes and archaebacteria.

@article{Inagaki2003AssessingFD,
  title={Assessing functional divergence in EF-1alpha and its paralogs in eukaryotes and archaebacteria.},
  author={Yuji Inagaki and Christian Blouin and Edward Susko and Andrew J. Roger},
  journal={Nucleic acids research},
  year={2003},
  volume={31 14},
  pages={4227-37}
}
A number of methods have recently been published that use phylogenetic information extracted from large multiple sequence alignments to detect sites that have changed properties in related protein families. In this study we use such methods to assess functional divergence between eukaryotic EF-1alpha (eEF-1alpha), archaebacterial EF-1alpha (aEF-1alpha) and two eukaryote-specific EF-1alpha paralogs-eukaryotic release factor 3 (eRF3) and Hsp70 subfamily B suppressor 1 (HBS1). Overall, the… CONTINUE READING

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